Does your dog struggle with fireworks or thunderstorms? Or does car travel induce horrible anxiety? Phobias and anxieties are more common than you may think in dogs and as much as we can do to comfort them with management and support, sometimes pharmaceutical intervention can be an excellent tool in the toolkit for relieving this stress.

What Is Trazodone for Dogs Used For

Key Takeaways:

Trazodone is the medication most commonly used to treat anxiety and stress in dogs.

It is commonly used for phobias, anxiety, compulsive behaviors, barking, aggression, separation anxiety, and post-surgery recovery.The dosage of trazodone for dogs varies based on their specific circumstances and size, and it is usually started at a lower dose and gradually increased if needed.

Your veterinarian can offer a few different drug options, and one of them is trazodone. Read on to find out more about trazodone for dogs, and if it might be the right medication for yours.

What Is Trazodone for Dogs Used For?

Trazodone is a medication commonly used in dogs to treat anxiety and stress. It acts as a serotonin antagonist and reuptake inhibitor (SARI), increasing serotonin levels in the brain to alleviate anxiety and promote relaxation. It’s often prescribed for separation anxiety, fear of loud noises, and anxiety related to veterinary visits or travel.

Main Uses of Trazodone for Dogs

Trazodone is most commonly used to treat phobias and anxiety in dogs, but it can also help with compulsive behaviors, excessive barking, and sometimes aggression. It helps keep pets calmer during stressful situations.

It is often prescribed to dogs to keep them calm for vet visits, grooming sessions, or during fireworks. Trazodone is also useful for dogs with separation anxiety, helping them cope when their owners leave for work.

Another common use is after surgery, helping dogs stay calm during cage rest for proper recovery and healing.

For dogs stressed by traveling, trazodone can be given before long car trips or flights to ease their anxiety.

Trazodone can also be used for long-term management of anxiety, administered daily over several weeks for full effect. If your dog has these anxieties or phobias, consult your veterinarian to see if trazodone could help.

Trazodone Dosage for Dogs

The trazodone dosage for dogs can vary and your veterinarian will advise you on what dose to start with based on your dog’s specific circumstances and size. The dosage range goes from 1.7 to 9.5 mg/kg orally every 8 to 24 hours. Your veterinarian will usually start your dog off at the lower end of the scale and gradually taper them up as needed.

Below is a table illustrating how much trazodone you can give your dog depending on how much it weighs.

Dog Weight (lbs) Dog Weight (kg) Low Dosage (in mg) High Dosage (in mg)
10 4.5 7.65 42.75
20 9.1 15.47 86.45
30 13.6 23.12 129.2
40 18.1 30.77 171.95
50 22.7 38.59 215.65
60 27.2 46.24 258.4
70 31.8 54.06 301.1
80 36.3 61.71 344.85
90 40.8 69.36 387.6
100 45.4 77.18 431.3
110 49.9 84.83 474.05
120 54.4 92.48 516.8
130 59.0 100.3 560.5
140 63.5 107.95 603.25
150 68.0 115.6 646.0
160 72.6 123.42 689.7
170 77.1 131.07 732.45
180 81.6 138.72 775.2
190 86.2 146.54 818.9
200 90.7 154.19 861.65

Trazodone Side Effects in Dogs

When considering the use of trazodone for dogs, it’s important to be aware of potential side effects. While these are generally uncommon, they can occur, especially when starting at low doses. Common side effects include:

  • Vomiting: Occasionally, dogs might experience vomiting after taking trazodone.
  • Diarrhea: Similarly, diarrhea might manifest as a side effect.
  • Sedation and Lethargy: Trazodone can cause sedation and lethargy, potentially affecting your dog’s activity levels.
  • Ataxia: Some dogs might exhibit ataxia, which is a lack of coordination or unsteadiness.
  • Hypotension: Trazodone can lead to low blood pressure in some cases.
  • Excitement and Agitation: Paradoxically, excitement and agitation can occur as side effects.
  • Panting: Increased panting might be observed, which could indicate a side effect.

If your dog experiences mild to moderate side effects, consult your veterinarian for guidance. Wait for the symptoms to subside and consider lowering the next trazodone dose.

For severe side effects, schedule an appointment with your veterinarian. Inform your vet about any other medications your dog is taking, as drug interactions may occur.

How Do You Help Dogs With Phobias?

There are a range of management, training, nutritional, and veterinary interventions that can be used for dogs who have behavioral disorders, including nutritional and behavioral consultation. If your dog struggles with loud noise phobias, you can help them by being present and ready to comfort them when you expect there to be fireworks or thunderstorms.

You can also create safe spaces for them in the house. This could be a crate with a blanket over the top with their dog bed and their favorite toy inside or another covered area with lots of blankets and cushions that smell familiar.


Trazodone is a versatile medication used in veterinary medicine primarily for managing anxiety and behavioral issues in dogs. It is particularly effective in reducing symptoms of anxiety related to travel, thunderstorms, fireworks, and separation. The dosage of trazodone for dogs varies based on factors such as the dog’s weight, age, and specific condition, typically ranging from 2.5 to 15 mg per kilogram of body weight, administered 1 to 2 times daily.

While trazodone is generally well-tolerated, it can cause side effects. Common side effects include sedation, lethargy, and gastrointestinal upset. In rare cases, dogs may experience more severe reactions such as serotonin syndrome, characterized by symptoms like confusion, rapid heart rate, and tremors. It is crucial for dog owners to follow their veterinarian’s dosage recommendations and monitor their pets for any adverse reactions.

Overall, trazodone is an effective option for managing canine anxiety and behavioral issues, offering significant relief when used appropriately under veterinary guidance. As with any medication, careful monitoring and adherence to prescribed dosages are essential to ensure the safety and well-being of the dog.

Frequently Asked Questions

How quickly does trazodone take effect in dogs?

Trazodone for dogs should start to take effect within 1 to 2 hours after administering it for short-term anxiety or phobia relief. When used for long-term anxiety management, it can take up to 2-3 weeks to see significant effects.

How long does trazodone last in dogs?

Trazodone’s effects on dogs can last approximately 6-24 hours. The actual duration may vary depending on the dog’s size, age, and overall health. Consult with a veterinarian before giving your dog trazodone to determine the appropriate dosage and duration of treatment.

Is it safe to give a dog trazodone every day?

Yes, it is usually recommended to give trazodone once every day for the long-term management of anxiety in your dog.

What happens if I give my dog too much trazodone?

If you give your dog too much trazodone, it can lead to severe side effects. If you suspect an overdose, seek immediate veterinary care.

Why is my dog shaking after trazodone?

Shaking or tremors in dogs after taking trazodone may be a sign of serotonin syndrome, a serious side effect. Serotonin levels can elevate, causing symptoms like restlessness, agitation, and tremors. If you notice these signs in your dog, seeking immediate veterinary care is crucial.

Can trazodone cause diarrhea in dogs?

Yes, trazodone can cause diarrhea in dogs as one of its potential side effects. While it is generally well tolerated, gastrointestinal effects such as vomiting and diarrhea can occur.